Bare Bones & Hormones — Part I

Hard Facts About Brittle Bones

Here’s a piece of information I’ll bet you didn’t know — osteoporosis can kill you. It killed my mother. It killed the mother of one of my oldest friends. My friend’s mother literally crumbled to death, in pain, in a hospital bed, when she couldn’t move anymore because her bones wouldn’t hold her up. My mother died because she had about twenty compression fractures in her spine from neck to hips, resulting in a spinal column that looked like the top of a coat hanger. Because of this deformity, her heart and lungs and intestinal organs were unable to work properly, thereby causing a lethal combination of poor nutritional absorption mixed with cardiac and respiratory distress. Half of all women and a quarter of all men over age 50 will experience a bone fracture due to osteoporosis, and of those who fracture a hip, one third of them will die within a few years of that fracture, fully one fifth within a year.

Here’s something else I’ll bet you didn’t know — for post-menopausal women, the risk of sustaining a fracture of the hip, wrist, pelvis, vertebra or other bone is far greater than the combined risk of having breast, ovarian and uterine cancer. A woman’s risk for a hip fracture alone is equal to her combined risk for breast, uterine and ovarian cancer. Even for breast cancer survivors, most of us are far more likely to develop osteoporosis and sustain a fracture than we are to have a cancer recurrence. Throw in the sudden loss of estrogen due to aromatase inhibitors and oophorectomies, and our risk for bone loss is even worse than average. As it is, it has been estimated that one in five of all U.S. Caucasian and Asian women over 50 have osteoporosis, and about half of all women over 50 have early, measurable bone loss, also known as osteopenia, which can lead to osteoporosis. I’m one of them. My recent bone density scan put my hip and lower back squarely in the osteopenia camp.

As a physical therapist, I can personally attest to the fact that an alarming percentage of women at risk for bone loss never have a bone density scan, even after they fracture something, even though the occurrence of a fracture, any fracture, at any age, is considered an indicative risk factor for osteoporosis. Other risk factors that predispose men and women to osteoporosis include a family history of fractures or osteoporosis, natural or surgically-induced menopause, disease, alcohol use, medication side effects, hyperthyroidism, cancer, and simply growing older. Even when a radiologist can see and thus report a finding of osteoporosis on a regular X-ray that may be taken to confirm a fracture, all too often there is still no follow-up bone density scan, no treatment offered for the osteoporosis, nothing beyond treatment of the fracture itself. And when osteoporosis treatment is offered, it is often inadequate or just plain wrong. I wish I had $5 for every time a patient of mine who has a history of gastric reflux or some other intestinal disorder is prescribed Fosamax or Boniva, which are both bisphosphonates, even though bisphosphonates are clearly identified as inappropriate for folks with gastro-intestinal problems. And because bisphosphonates make their heartburn or ulcers worse, my patients will stop taking them, never getting some other kind of treatment to replace them. It’s enough to make a PT completely insane.

Estrogen — Friend or Foe?

Naturally, when you throw breast or ovarian cancer into the equation, it makes things more complicated. Most of us are aware of the big hormone replacement study that was suspended in 2002 because of the increases in heart disease and blood clots among the subjects. I could go on at some length about how the actual statistical significance of these increases was taken out of context and thereby inflated by the media, but I’ll spare you. And many of us know that after the suspension of this study, when droves of women on any kind of HRT suddenly stopped it, reports eventually came out crediting cessation of HRT for a decreased incidence of breast cancer. However, there was also a corresponding increase in osteoporosis. And I don’t remember any big splashy news reports about that. I have personally treated several women who suddenly stopped HRT in 2002, but did not replace it with anything, and consequently experienced a sudden loss of bone density resulting in pain, spinal deformity, fractures and lifelong disability. And aside from prescribing pain killers, their doctors have often done nothing to help them.

My mother, who died one year before Fosamax hit the market in 1995, brought on her own osteoporosis the same way. She had been taking HRT for several years, decided she was sick of it and stopped it, without informing her doctor, without taking a calcium supplement, and without any follow-up screening for bone density. Within five years, she developed the twenty compression fractures which were only discovered when an acute inability to pick up her head caused me to march her into her doctor’s office and demand an X-ray of her spine. It turned out to be the first spinal imaging this doctor had ever ordered for her, even though she’d been treating my increasingly humped-back mother for several years. The X-ray showed what any nitwit could see by looking at her, which is that she had by then developed severe spinal kyphosis due to osteoporosis. I was 35 at the time, and so help me, I wanted to slap this doctor upside the head. I didn’t. But I vowed at that moment that I would do everything I could to prevent the same fate for myself and others if I could.

“The Sky Is Falling! The Sky Is Falling!”

What I did was go to graduate school and become a PT, and later get certified training as an osteoporosis educator. Every year since, I’ve delivered at least one public education session about the disease. HRT has been much maligned, but in moderation, with proper monitoring by a physician, it is sometimes the best thing for treating the symptoms of menopause and preserving bone density while formulating a long-term strategy. And at least now, there are several non-hormonal options for treating bone loss, including a number of medications and nutritional supplements known to prevent or even reverse it, so that even when we lose our estrogen, we don’t have to crumble. Yet osteoporosis continues to be under-evaluated and under-treated. And for us cancer survivors and previvors and BRCA mutants, there are these oncologists running around like Chicken Little, hollering about how estrogen is bad, Bad, BAD, and trying to convince us to ferret out every last dastardly molecule. Well, forgive me if I am forced to holler back by pointing out once again that estrogen is not the enemy. Cancer is the enemy.

Nothing is ever simple where cancer is concerned and I’m about to make it even more confusing. But let me start with an assertion or three that has finally found a basis in medicine, unless you are one of those blinkered oncologists who have evidently forgotten that they wouldn’t be here, torturing us in the first place, were it not for estrogen. Assertion #1: Estrogen happens to be a remarkably useful substance. In addition to playing a rather key role in the continuation of the species, it makes us female, it helps our skeletons to develop in childhood and keeps them strong in adulthood; it helps us produce collagen to keep our skin and joints pliable; it keeps us from developing heart disease and strokes and high cholesterol; and it helps us think and focus. Pretty good stuff. Assertion #2, therefore, is that when our estrogen levels fluctuate, we certainly notice, whether it’s due to our monthly mensis or to pregnancy or to the first stirrings of peri-menopause. And Assertion #3 is that, when those levels plummet, with childbirth or oophorectomy or aromatase inhibitors or regular old menopause, our emotional and physical well-being can plummet as well. And finally, Assertion #4, estrogen is NOT the easily expendable substance that cancer docs may try to make us believe. Oh, and guess what? Removing its sources or preventing it from circulating in our bodies does not keep us from ever getting cancer. Yes, it may reduce the statistical likelihood, but it’s no guarantee.

Here’s where it gets complicated. We know that many breast cancers and ovarian cancers feed on estrogen. Research published earlier this year in the journal Cancer Research found that estrogen appears to suppress cancer-cell death somehow in estrogen-receptor-positive breast cancer, but very little is understood about why. Additional recent studies found that, rather than a single gene like BRCA, it appears that a group of genes may work in concert to enable hormone-sensitive breast and endometrial cancers to develop in the first place. These kinds of studies show promise for facilitating the development of therapies targeted at the actual mechanisms of tumor development. But in the meantime, in that kill-a-gnat-with-a-sledge-hammer approach characterizing much of cancer treatment, it’s easy to pick on estrogen itself and try to remove it from the equation altogether, despite what havoc that may wreak.

On the other hand, it has been documented for several years now that women who live in Asia and eat an Asian diet, which is typically high in soy products, low in animal fat and high in vegetables and fiber, have a significantly lower incidence of breast cancer than women in Western countries, who eat more animal fats and fewer vegetables. This observation has led to numerous studies about soy, isoflavones, phytoestrogens and other substances to see if there are further correlations between them and the increase or decrease of breast cancer risk. Unfortunately, there have been some compelling studies on both sides of the fence in the past several years. However, an excellent review of the research on this subject was published in Nutrition Journal 2008, 7:17 which concluded,

    “In this analysis and commentary we attempt to outline current concerns regarding the estrogen-like effects of isoflavones in the breast focusing primarily on the clinical trial data and place these concerns in the context of recent evidence regarding estrogen therapy use in postmenopausal women. Overall, there is little clinical evidence to suggest that isoflavones will increase breast cancer risk in healthy women or worsen the prognosis of breast cancer patients.”

In fact, another study, published in the Journal of Clinical Oncology in 2005 found that, “Short-term HRT use does not negate the protective effect of [bilateral prophylactic oophorectomy] on subsequent breast cancer risk in BRCA1/2 mutation carriers.” This means that post-oophorectomy BRCA women can safely use real hormone therapy to mitigate the sudden onset of menopause and its symptoms after losing their ovaries and thus their chief source of estrogen. And they can continue to use phytoestrogens from soy and other foods after HRT to continue to treat those symptoms. All of this is good news for our bones as well, because there are now prescription and over-the-counter soy estrogen supplements available that have been demonstrated to effectively prevent osteoporosis.

All of this tells only part of the story of this complex relationship between breast cancer, estrogen and the prevention and treatment of bone loss. And that means there will be another blog post or two on the subject. So, stay tuned.


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This entry was written by Kathi, posted on Wednesday, July 28, 2010 at 01:07 am, filed under Diagnosis, Recurrence, Screening, Health & Healthcare, Making A Difference, Nitty Gritty, Pain & Neuropathy, Survivorship and tagged , , , , , , , , , , . Bookmark the permalink . Post a comment below or leave a trackback: Trackback URL.

8 Responses to “Bare Bones & Hormones — Part I”

  1. Well done blog. My great aunt’s spine crumbled on her to the point that she wore a morphine pump to control the pain.

    I recently blogged about surgical menopause (which will happen to me this week) and bone loss also: http://positiveresultsthebook.blogspot.com/2010/07/adios-ovaries.html

    Joi

  2. Thanks Kathi, I am fortunate to have an internist who does take this very seriously. It is a vitally important topic.

    Joi

  3. Brilliant advice for intervention and recognition of Osteoporosis. Few doctors know about or discuss the topic of Bone Health.

    I am so sorry to read that your mother suffered with Osteoporosis. Women are diagnosed with it, yet have no symptoms, and don’t think of Osteoporosis as a seriously, debilitating disease. Hopefully, your message will reach many, and more research will help to save lives, and quality of life. You are truly, a valiant, dauntless Amazon hero~ opening the doors to knowledge, guidance, hope…

    What exactly is Degenerative Bone Disease? Searching for answers is so frustrating!

    Thank you, Kathi, again… xoxoxo

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